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alli blocks 25% of the fat you eat from being absorbed, and the fat that isn't absorbed is harmlessly passed through your bowels. As a result, you may experience some bowel changes during the first few weeks of use. These treatment effects are most likely to occur after taking an alli capsule and eating a meal containing more than 15 grams of fat. Staying below your fat threshold lowers the chance of these treatment effects. If you do experience a treatment effect, it may be because you've gone beyond your target. It's helpful to think of these effects as reminders from your body that you need to stick to lower-fat foods.